Spicy Southern Cheesy Chicken Spaghetti Casserole

Why You’ll Love This Recipe

This casserole combines the richness of cheese and cream with the bold flavors of paprika and cayenne pepper. It’s a versatile, one-dish meal that’s easy to make, freezer-friendly, and sure to please both kids and adults. The balance of spice and creaminess makes it unique compared to traditional chicken casseroles.

Ingredients

(Tip: You’ll find the full list of ingredients and measurements in the recipe card below.)

• 3–4 boneless, skinless chicken breasts (about 1.5 lbs)
• 8 oz spaghetti
• 2 cups shredded sharp cheddar cheese
• 1 cup fresh bell peppers, chopped
• 1 can (10.5 oz) cream of chicken soup
• 1 tsp paprika
• 1/2 tsp cayenne pepper
• 1 tsp garlic powder
• 1/4 cup green onions, sliced

Directions

1. Preheat the oven to 350°F (175°C) and grease a large casserole dish.

2. Cook chicken in a skillet over medium heat for 6–7 minutes per side until golden and cooked through. Shred once slightly cooled.

3. Bring salted water to a boil and cook spaghetti until al dente, about 8–10 minutes. Drain and set aside.

4. In a large bowl, combine shredded chicken, spaghetti, cream of chicken soup, bell peppers, spices, and half of the cheddar cheese. Mix until evenly coated.

5. Transfer the mixture into the prepared casserole dish. Top with the remaining cheddar cheese.

6. Bake for 25–30 minutes until bubbly and golden brown.

7. Remove from oven, let rest for 5 minutes, and garnish with chopped green onions before serving.

Servings and timing

This recipe serves 8 people. Prep time is about 15 minutes, cook time is 30 minutes, making the total time approximately 45 minutes.

Variations

• Swap cheddar for Monterey Jack or pepper jack cheese for a different flavor.

• Add jalapeños for extra heat.

• Substitute spaghetti with penne, rotini, or linguine.

• Use rotisserie chicken for a shortcut.

• Mix in a can of Rotel tomatoes for a tangy twist.

Storage/Reheating

Store leftovers in an airtight container in the refrigerator for up to 4 days. To reheat, warm in the oven at 350°F until heated through, or microwave individual portions. For longer storage, freeze the casserole (before or after baking) for up to 2 months. If frozen unbaked, thaw overnight in the fridge before baking.

FAQs

How spicy is this casserole?

The spice level is mild to medium, depending on how much cayenne pepper you use. You can adjust to taste.

Can I use pre-cooked chicken?

Yes, rotisserie chicken or leftover cooked chicken works perfectly.

Can I make this casserole ahead of time?

Absolutely. Assemble the casserole, cover tightly, and refrigerate for up to 24 hours before baking.

What can I serve with this casserole?

A side salad, garlic bread, or roasted vegetables pair beautifully with this dish.

Can I make this casserole vegetarian?

Yes, swap chicken for mushrooms, zucchini, or plant-based chicken substitutes.

How do I prevent the casserole from drying out?

Make sure not to overcook the pasta before baking and cover with foil if needed while reheating.

Can I use different soups?

Yes, cream of mushroom or cream of celery soup are great substitutes.

Can I add more vegetables?

Definitely. Try adding corn, spinach, or broccoli for extra nutrition.

Can I make it less creamy?

Use half the amount of soup and add chicken broth for a lighter version.

Can I freeze individual portions?

Yes, divide leftovers into freezer-safe containers for easy, single-serve meals.

Conclusion

Spicy Southern Cheesy Chicken Spaghetti Casserole is a flavorful, comforting dish that’s perfect for any occasion. Its creamy texture, cheesy topping, and touch of spice make it an unforgettable meal. Whether you’re cooking for family, friends, or meal prepping for the week, this casserole is a winning choice.

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